OPM, a three-letter acronym or abbreviation, may refer to:

Organizations

• Office of Personnel Management, the federal civil service in the United States
• Organisasi Papua Merdeka (the Free Papua Movement), Indonesia
• Old Plymothian and Mannameadian a.k.a an OPM, an ex-pupil of Plymouth College, Devon, UK
• OPM (comedy), Asian American sketch comedy troup
• Political Military Organization (Organización Político Militar) Paraguayan clandestine movement

Music

• OPM (band), a United States band
• Original Pilipino Music, a genre of music
• Original Pirate Material, an album by The Streets

Science and technology

• Object Process Methodology
• Organisational Project Management Maturity Model (OPM3)
• PVP-OPM (Protected Video Path - Output Protection Management), a form of Digital Rights Management
• Optical Performance Monitoring, used for managing high capacity optical transmission and switching systems
• Orientations of Proteins in Membranes database

Other

• Other People's Money, a 1991 movie starring Danny DeVito
• Official U.S. PlayStation Magazine
• Old Plymothian and Mannameadian, a former pupil of Plymouth College, England
• Olimpíadas Portuguesas de Matemática, the Portuguese Mathematics Olympiads
• Outsourced program management or Outsourced program manager (Affiliate marketing)
• Operating Profit Margin
• Operational Performance Measures
• Black“Scholes Option Pricing Model
• Opium

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